Overview

  • Product name

    Cevimeline hydrochloride, M1 and M3 receptor agonist
  • Description

    Selective M1 and M3 receptor agonist
  • Biological description

    Selective M1 and M3 receptor agonist. Induces atropine-sensitive contractions of ilea and trachea (EC50 values are 3.5 and 3 μM, respectively). Reverses AF64A-induced cognitive impairments and promotes saliva secretion in vivo.
  • CAS Number

    107220-28-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    cis-2-Methylspiro[1,3-oxathiolane-5­,3'-quinuclidine] hydrochloride
  • Molecular weight

    235.77
  • Molecular formula

    C10H17NOS.HCl
  • PubChem identifier

    9837584
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1OC2(CN3CCC2CC3)CS1.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Greig NH  et al. New pharmacological approaches to the cholinergic system: an overview on muscarinic receptor ligands and cholinesterase inhibitors. Recent Pat CNS Drug Discov 8:123-41 (2013). Read more (PubMed: 23597304) »
  • Nakamura M  et al. An Immunohistochemistry-Based Study on Aquaporin (AQP)-1, 3, 4, 5 and 8 in the Parotid Glands, Submandibular Glands and Sublingual Glands of Sjögren's Syndrome Mouse Models Chronically Administered Cevimeline. Kurume Med J 60:7-19 (2013). Read more (PubMed: 23925155) »
  • Chambon C  et al. Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication. Eur J Pharmacol 697:73-80 (2012). Read more (PubMed: 23085025) »

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