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Immunology Cell Type Markers CD Endothelial Cells
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CF405M Anti-CD105 antibody [2H6F11], prediluted (ab123634)

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Flow Cytometry - CF405M Anti-CD105 antibody [2H6F11], prediluted (ab123634)

    Key features and details

    • CF405M Mouse monoclonal [2H6F11] to CD105, prediluted
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Conjugation: CF405M. Ex: 408nm, Em: 452nm
    • Isotype: IgG1

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    Overview

    • Product name

      CF405M Anti-CD105 antibody [2H6F11], prediluted
      See all CD105 primary antibodies
    • Description

      CF405M Mouse monoclonal [2H6F11] to CD105, prediluted
    • Host species

      Mouse
    • Conjugation

      CF405M. Ex: 408nm, Em: 452nm
    • Tested Applications & Species

      Application Species
      Flow Cyt
      Human
      See all applications and species data
    • Immunogen

      Human Endoglin fusion protein.

    • Positive control

      • Nalm-6 cell line
    • General notes


      CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.

      CF405M (Abs/Em Max: 408/450nm). Direct replacement for Pacific Blue dye®, BD Horizon™ V450.

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

      One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

      Learn more here.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C.
    • Storage buffer

      pH: 7.20
      Preservative: 0.09% Sodium azide
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Primary antibody notes

      CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.
    • Clonality

      Monoclonal
    • Clone number

      2H6F11
    • Isotype

      IgG1
    • Research areas

      • Immunology
      • Cell Type Markers
      • CD
      • Endothelial Cells
      • Stem Cells
      • Mesenchymal Stem Cells
      • Surface Molecules
      • Cancer
      • Tumor biomarkers
      • Other
      • Cardiovascular
      • Vasculature
      • Endothelium
      • Stem Cells
      • Endothelial Progenitors
      • Endothelial Markers
      • Cardiovascular
      • Cardiovascular Markers
      • Cell Markers
      • Endothelial Cells
      • Cardiovascular
      • Angiogenesis
      • Endothelial Cell Markers

    Associated products

    • Alternative Versions

      • PerCP Anti-CD105 antibody [2H6F11] (ab91138)
    • Isotype control

      • CF405M Mouse IgG1, Kappa Monoclonal [B11/6] - Isotype Control (ab126026)
    • Recombinant Protein

      • Recombinant human CD105 protein (ab54338)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab123634 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    Flow Cyt
    Human
    Application Abreviews Notes
    Flow Cyt
    Use 5µl for 106 cells.

    ab126026 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

     

    Notes
    Flow Cyt
    Use 5µl for 106 cells.

    ab126026 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

     

    Target

    • Function

      Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
    • Tissue specificity

      Endoglin is restricted to endothelial cells in all tissues except bone marrow.
    • Involvement in disease

      Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P17813 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 2022 Human
      • Omim: 131195 Human
      • SwissProt: P17813 Human
      • Unigene: 76753 Human
      • Alternative names

        • AI528660 antibody
        • AI662476 antibody
        • CD 105 antibody
        • CD105 antibody
        • CD105 antigen antibody
        • EGLN_HUMAN antibody
        • END antibody
        • Endoglin antibody
        • Eng antibody
        • FLJ41744 antibody
        • HHT1 antibody
        • ORW antibody
        • ORW1 antibody
        • Osler Rendu Weber syndrome 1 antibody
        • RP11 228B15.2 antibody
        • S endoglin antibody
        • S-endoglin antibody
        • SN6 antibody
        see all

      Images

      • Flow Cytometry - CF405M Anti-CD105 antibody [2H6F11], prediluted (ab123634)
        Flow Cytometry - CF405M Anti-CD105 antibody [2H6F11], prediluted (ab123634)
        Staining of Nalm-6 cell line with ab123634 at 5 µl/106 cells and isotype control IgG1 CFBlue. Total cells were used for analysis.

      Protocols

      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab123634? Please let us know so that we can cite the reference in this datasheet.

      ab123634 has not yet been referenced specifically in any publications.

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