Key features and details
- CF405M Mouse monoclonal [2H6F11] to CD105, prediluted
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: CF405M. Ex: 408nm, Em: 452nm
- Isotype: IgG1
Product nameCF405M Anti-CD105 antibody [2H6F11], prediluted
See all CD105 primary antibodies
DescriptionCF405M Mouse monoclonal [2H6F11] to CD105, prediluted
ConjugationCF405M. Ex: 408nm, Em: 452nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Human
Human Endoglin fusion protein.
- Nalm-6 cell line
CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.
CF405M (Abs/Em Max: 408/450nm). Direct replacement for Pacific Blue dye®, BD Horizon™ V450.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Primary antibody notesCD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.
Our Abpromise guarantee covers the use of ab123634 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use 5µl for 106 cells.
ab126026 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionMajor glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Tissue specificityEndoglin is restricted to endothelial cells in all tissues except bone marrow.
Involvement in diseaseDefects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
- Information by UniProt
- AI528660 antibody
- AI662476 antibody
- CD 105 antibody
ab123634 has not yet been referenced specifically in any publications.