Key features and details
- CF405M Rat monoclonal [GK1.5] to CD4
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: CF405M. Ex: 408nm, Em: 452nm
- Isotype: IgG2b
Related conjugates and formulations
Product nameCF405M Anti-CD4 antibody [GK1.5]
See all CD4 primary antibodies
DescriptionCF405M Rat monoclonal [GK1.5] to CD4
ConjugationCF405M. Ex: 408nm, Em: 452nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Mouse
Tissue, cells or virus corresponding to Mouse CD4. (Mouse CTL clone V4).
- Flow Cyt: Mouse splenocytes.
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Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Concentration information loading...
Purification notesPurified from an in vitro cell culture of a cell hybridoma.
Light chain typekappa
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab237029 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 1µg for 106 cells.
Use 1µg for 106 cells.
FunctionAccessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Sequence similaritiesContains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localizationCell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
- Information by UniProt
- CD 4 antibody
- CD4 (L3T4) antibody
- CD4 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab237029 has not yet been referenced specifically in any publications.