Overview

  • Product name

    CFM-4, CARP-1 mimetic
  • Description

    CARP-1 mimetic
  • Biological description

    CARP-1 mimetic. Interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Shows antiproliferative effects in cancer cell lines.
  • CAS Number

    331458-02-7
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    405.90
  • Molecular formula

    C22H16ClN3OS
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Clc5ccccc5CN4c1ccccc1C2(NN=C(S2)c3ccccc3)C4=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Muthu M  et al. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget 6:6499-510 (2015). Read more (PubMed: 25894788) »
  • Jamal S  et al. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells. PLoS One 9:e89146 (2014). Read more (PubMed: 24598827) »
  • Muthu M  et al. Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics. PLoS One 9:e102567 (2014). Read more (PubMed: 25033461) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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