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    cftr-antibody-carboxyterminal-end-ab56058.pdf

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Anti-CFTR antibody - Carboxyterminal end (ab56058)

  • Datasheet
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Key features and details

  • Rabbit polyclonal to CFTR - Carboxyterminal end
  • Reacts with: Recombinant fragment
  • Isotype: IgG

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Protein
Product image
Recombinant Human CFTR protein (ab114246)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-CFTR antibody - Carboxyterminal end
    See all CFTR primary antibodies
  • Description

    Rabbit polyclonal to CFTR - Carboxyterminal end
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Sheep, Human
  • Immunogen

    A synthetic peptide corresponding to C-terminal residues of human CFTR (Cystic fibrosis transmembrane conductance regulator)

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol (glycerin, glycerine), PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Other Antibodies
    • Other Antibodies
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human CFTR protein (ab114246)

Target

  • Function

    Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
  • Tissue specificity

    Found on the surface of the epithelial cells that line the lungs and other organs.
  • Involvement in disease

    Defects in CFTR are the cause of cystic fibrosis (CF) [MIM:219700]; also known as mucoviscidosis. CF is the most common genetic disease in the Caucasian population, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive. CF is a common generalized disorder of exocrine gland function which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes.
    Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD) [MIM:277180]. CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
  • Sequence similarities

    Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Domain

    The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
  • Post-translational
    modifications

    Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites.
    Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling.
  • Cellular localization

    Early endosome membrane.
  • Target information above from: UniProt accession P13569 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 1080 Human
    • Entrez Gene: 443347 Sheep
    • Omim: 602421 Human
    • SwissProt: P13569 Human
    • SwissProt: Q00555 Sheep
    • Unigene: 489786 Human
    • Unigene: 621460 Human
    • Unigene: 661104 Human
    • Alternative names

      • ABC 35 antibody
      • ABC35 antibody
      • ABCC 7 antibody
      • ABCC7 antibody
      • ATP binding cassette sub family C member 7 antibody
      • ATP Binding Cassette Superfamily C Member 7 antibody
      • ATP binding cassette transporter sub family C member 7 antibody
      • ATP-binding cassette sub-family C member 7 antibody
      • cAMP dependent chloride channel antibody
      • cAMP-dependent chloride channel antibody
      • CF antibody
      • CFTR antibody
      • CFTR/MRP antibody
      • CFTR_HUMAN antibody
      • Channel conductance controlling ATPase antibody
      • Channel conductance-controlling ATPase antibody
      • Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) antibody
      • Cystic fibrosis transmembrane conductance regulator antibody
      • Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7 antibody
      • Cystic Fibrosis Transmembrane Regulator antibody
      • dJ760C5.1 antibody
      • MRP 7 antibody
      • MRP7 antibody
      • TNR CFTR antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab56058? Please let us know so that we can cite the reference in this datasheet.

    ab56058 has been referenced in 1 publication.

    • Riquelme SA  et al. Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity. Immunity 47:1169-1181.e7 (2017). PubMed: 29246444

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