Overview

  • Product name

    cGAMP disodium salt, STING agonist
  • Description

    Potent STING agonist
  • Biological description

    Potent STING agonist. Effective concentration in mouse cells at 10 nM. Second messenger that triggers interferon production in response to cytosolic DNA. Active in vitro.
  • Purity

    > 98%
  • CAS Number

    849214-04-6
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    718.37
  • Molecular formula

    C20H24N10Na2O13P2
  • PubChem identifier

    71563406
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3NC(=NC4=O)N)OP(=O)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C=NC7=C6N=CN=C7N)O)OP(=O)(O1)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Downey CM  et al. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 9:e99988 (2014). Read more (PubMed: 24940883) »
  • Wu J  et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339:826-30 (2013). Read more (PubMed: 23258412) »
  • Li XD  et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341:1390-4 (2013). Read more (PubMed: 23989956) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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