Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.60
Preservative: 0.02% Sodium azide
Constituents: 69% Tris glycine, 30% Glycerol
pH 7.4 - 7.8
Stabilizing proteins (0.5%)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab176177 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500. Predicted molecular weight: 59 kDa.|
FunctionNucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
Tissue specificityExpressed in the monocytic cell line THP1.
Sequence similaritiesBelongs to the mab-21 family.
Cellular localizationCytoplasm > cytosol.
- Information by UniProt
- C6orf150 antibody
- cGAMP synthase antibody
- cGAS antibody
This product has been referenced in:
- Wang L et al. Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science 365:N/A (2019). Read more (PubMed: 31320558) »
- Tian J et al. Feline Herpesvirus 1 US3 Blocks the Type I Interferon Signal Pathway by Targeting Interferon Regulatory Factor 3 Dimerization in a Kinase-Independent Manner. J Virol 92:N/A (2018). Read more (PubMed: 29618645) »