Overview

  • Product name

    CGK 733, ATR and ATM kinase inhibitor
  • Description

    Selective ATR and ATM kinase inhibitor
  • Biological description

    Selective ATR and ATM kinase inhibitor. Shows antiproliferative effects in a range of cancer cell lines. Blocks recruitment and hyperphosphorylation of RPA2.
  • Purity

    > 99%
  • CAS Number

    905973-89-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Williams TM  et al. Molecular imaging of the ATM kinase activity. Int J Radiat Oncol Biol Phys 86:969-77 (2013). Read more (PubMed: 23726004) »
  • Cruet-Hennequart S  et al. Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair (Amst) 7:582-96 (2008). Read more (PubMed: 18289945) »
  • Won J  et al. Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol 2:369-74 (2006). Read more (PubMed: 16767085) »
See 1 Publication for this product

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