- References (3)
Product nameCGP 37157
DescriptionNa+-Ca2+ exchange inhibitor
Biological descriptionSelective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Ion pumps / transporter
- Na+/Ca2+ exchange
This product has been referenced in:
- Baron KT & Thayer SA CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur J Pharmacol 340:295-300 (1997). Read more (PubMed: 9537826) »
- Cox DA et al. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J Cardiovasc Pharmacol 21:595-9 (1993). Read more (PubMed: 7681905) »
- Cox DA & Matlib MA Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na(+)-Ca2+ exchange. Trends Pharmacol Sci 14:408-13 (1993). Read more (PubMed: 8296399) »