CGP 37157, Na+-Ca2+ exchange inhibitor (ab120012)

Submit a review Q&A (2)References (3)

Overview

  • Product name
    CGP 37157, Na+-Ca2+ exchange inhibitor
  • Description
    Na+-Ca2+ exchange inhibitor
  • Biological description
    Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
  • Purity
    > 99%
  • CAS Number
    75450-34-9
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Baron KT & Thayer SA CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur J Pharmacol 340:295-300 (1997). Read more (PubMed: 9537826) »
  • Cox DA  et al. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J Cardiovasc Pharmacol 21:595-9 (1993). Read more (PubMed: 7681905) »
  • Cox DA & Matlib MA Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na(+)-Ca2+ exchange. Trends Pharmacol Sci 14:408-13 (1993). Read more (PubMed: 8296399) »
See all 3 Publications for this product

Publishing research using ab120012? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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1-2 of 2 Abreviews or Q&A

Question

Our customer applied 6.17 ml of water into the vial and stored it forabout 1 hr in RT before use. (The lab temperature is 20C)
She compared this product to other brand and Ascent doesn't have mention about light sensitive.
Is this light sensitive product?

Best regards,

Read More
Answer

Thank you for your email.

I spoke to the experts in the lab about the solubility issues with this product.

They would like to make your customer aware that ab120012 has a low solubility in water. Therefore it may need prolonged stirring/agitation and warming to 40-50 degrees in order to get it into solution.

It might also help if it is less concentrated, for example 1mM in water.

I can confirm that we are not aware of any issues regarding light sensitivity.

I hope these tips will help dissolve ab120012. Please let me know if the problem persists.

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Question

Dear technical team,

Our customer received #ASC-012(ab120012, 10mg) two weeks ago and tried to dissolve it following instruction (water) but,

it didn't dissolve at all.

Lot#APN07045-4-2

She has complaint this item.

If you need information about this, let me know.


Best regards,

Read More
Answer

Thank you and your customer for taking the time to contact us. I am sorry to hear your customer has had difficulty disolving this product.

Reviewing this case, I would like to offer some suggestions to help optimise the results from ab120012:

1.) This product is soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM. Could you customer please let me know how much water was added to the 10mg? I can confirm that mistakes are easily done with these calculation from my own experience and your customer may want to double check.

2.) Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. I also suggest to warm the reconstituted solution to 23C (room temperature) to enable full solvation

We are happy to offer this technical support. In the event that a product is not functioning in the applications cited on the product data sheet (and the problem has been reported within 6 months of purchase), we will be pleased to provide a credit note, free of charge replacement or refund.

I hope this information is helpful, thank you and your customer for your cooperation. Should the suggestions not improve the results, please do not hesitate to contact me again with the further requested details.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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