CGP 37157, Na+-Ca2+ exchange inhibitor (ab120012)
Key features and details
- Na+-Ca2+ exchange inhibitor
- CAS Number: 75450-34-9
- Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CGP 37157, Na+-Ca2+ exchange inhibitor -
Description
Na+-Ca2+ exchange inhibitor -
Biological description
Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
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CAS Number
75450-34-9 -
Chemical structure
Properties
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Chemical name
7-Chloro-5-(2-chlorophenyl)-1,2,3,5-tetrahydro-4,1-benzothiazepin-2-one -
Molecular weight
324.22 -
Molecular formula
C15H11Cl2NOS -
PubChem identifier
2688 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc3ccccc3C1SCC(=O)Nc2ccc(Cl)cc12 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - CGP 37157, Na+-Ca2+ exchange inhibitor (ab120012)2D chemical structure image of ab120012, CGP 37157, Na+-Ca2+ exchange inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120012 has been referenced in 4 publications.
- Agarwal A et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93:587-605.e7 (2017). PubMed: 28132831
- Bondarenko AI et al. Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria. Pflugers Arch : (2013). PubMed: 23397170
- Parnis J et al. Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. J Neurosci 33:7206-19 (2013). PubMed: 23616530
- Jean-Quartier C et al. Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol 353:114-27 (2012). PubMed: 22100614