Key features and details
- Na+-Ca2+ exchange inhibitor
- CAS Number: 75450-34-9
- Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameCGP 37157, Na+-Ca2+ exchange inhibitor
DescriptionNa+-Ca2+ exchange inhibitor
Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Ion pumps / transporter
- Na+/Ca2+ exchange
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120012 has been referenced in 4 publications.
- Agarwal A et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93:587-605.e7 (2017). PubMed: 28132831
- Bondarenko AI et al. Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria. Pflugers Arch : (2013). PubMed: 23397170
- Parnis J et al. Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. J Neurosci 33:7206-19 (2013). PubMed: 23616530
- Jean-Quartier C et al. Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol 353:114-27 (2012). PubMed: 22100614