Key features and details
- Competitive NMDA antagonist
- CAS Number: 127910-31-0
- Soluble in water to 100 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product nameCGP 37849, competitive NMDA antagonist
DescriptionCompetitive NMDA antagonist
Competitive NMDA receptor antagonist (Ki = 35 nM for displacement of CPP binding in rat brain). Potent oral anticonvulsant activity in vivo.
Chemical name(E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120127 has been referenced in 2 publications.
- Du H et al. Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. J Neurosci 33:15022-31 (2013). PubMed: 24048832
- Homma R et al. In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb. Front Neural Circuits 7:23 (2013). PubMed: 23459031