CGP 52432, GABAB antagonist (ab120330)
- Datasheet
- References (9)
Overview
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Product name
CGP 52432, GABAB antagonist -
Description
Potent GABAB antagonist -
Biological description
Potent, selective GABAB antagonist (IC50 = 85 nM).
Also available in simple stock solutions (ab146709) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
139667-74-6 -
Chemical structure
Properties
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Chemical name
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl(diethoxymethyl)phosphinic acid -
Molecular weight
384.24 -
Molecular formula
C15H24Cl2NO4P -
PubChem identifier
132252 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(CNCCCP(=O)(O)C(OCC)OCC)cc1Cl -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Pan BX et al. Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron 61:917-29 (2009). Read more (PubMed: 19324000) »
- Bon C & Galvan M Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro. Br J Pharmacol 118:961-7 (1996). Read more (PubMed: 8799569) »
- Lanza M et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol 237:191-5 (1993). Read more (PubMed: 8103461) »
