Key features and details
- Potent, selective GABAB antagonist
- CAS Number: 149184-22-5
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameCGP 55845 hydrochloride, GABAB antagonist
DescriptionPotent, selective GABAB antagonist
- CGP55845 hydrochloride
Chemical name[(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist
5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.
(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120337 has been referenced in 25 publications.
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Chittajallu R et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194
- Weyrer C et al. The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep 26:2289-2297.e3 (2019). PubMed: 30811980
- McIver EL et al. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons. Cell Rep 28:992-1002.e4 (2019). PubMed: 31340159
- Cornford JH et al. Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies. Elife 8:N/A (2019). PubMed: 31657720