Anti-CGRP antibody (ab195387)
- Datasheet
- References
- Protocols
Overview
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Product nameAnti-CGRP antibody
See all CGRP primary antibodies -
DescriptionSheep polyclonal to CGRP
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Host speciesSheep
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Tested applicationsSuitable for: IHC-Pmore details
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Species reactivityReacts with: Rat, Rabbit, Human
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Immunogen
Synthetic peptide corresponding to Rat CGRP. (alpha).
Database link: P01256 -
Positive control
- Rat thoracolumbar spinal cord tissue.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
PurityAmmonium Sulphate Precipitation
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab195387 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/1000. Perfusion fixation is recommended if possible. |
Target
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RelevanceCGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
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Cellular localizationEndoplasmic reticulum and Secreted
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Database links
- Entrez Gene: 796 Human
- Entrez Gene: 797 Human
- Entrez Gene: 171519 Rat
- Entrez Gene: 24241 Rat
- Omim: 114130 Human
- Omim: 114160 Human
- SwissProt: P01258 Human
- SwissProt: P06881 Human
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Alternative names
- Calcitonin/calcitonin related polypeptide alpha antibody
- Alpha type CGRP antibody
- Beta type CGRP antibody
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Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (ab195387)Immunohistochemical analysis of paraffin-embedded Rat thoracolumbar spinal cord tissue labeling CGRP with ab195387 at 1/1000 dilution. Negative images of fluorescence detection procedure (Alexa488 conjugated secondary antibody).
Protocols
References
ab195387 has not yet been referenced specifically in any publications.
