• Product name
  • Description
    Sheep polyclonal to CGRP
  • Host species
  • Specificity
    On rat spinal cord immunostaining may be abolished by preincubation with 10nmol CGRP (rat alpha) per mL diluted antiserum. Neither substance P nor galanin have any effect on immunostaining when used at 10nmol/mL diluted antiserum. It is believed that ab22560 cross-reacts with all known forms of rat and human CGRP.
  • Tested applications
    Suitable for: ICC/IF, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Rat CGRP conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • Rat spinal cord.



Our Abpromise guarantee covers the use of ab22560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 24042033
IHC-FoFr 1/2000 - 1/4000.


  • Relevance
    CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
  • Cellular localization
    Endoplasmic reticulum and Secreted
  • Database links
  • Alternative names
    • Calcitonin/calcitonin related polypeptide alpha antibody
    • Alpha type CGRP antibody
    • Beta type CGRP antibody
    • CALC1 antibody
    • CALC2 antibody
    • CALCA antibody
    • CALCB antibody
    • Calcitonin 1 antibody
    • Calcitonin 2 antibody
    • Calcitonin gene related peptide I antibody
    • Calcitonin gene related peptide II antibody
    • Calcitonin related polypeptide alpha antibody
    • Calcitonin related polypeptide beta antibody
    • CGRP antibody
    • CGRP I antibody
    • CGRP II antibody
    • CGRP1 antibody
    • CGRP2 antibody
    • CT antibody
    • Katacalcin antibody
    • KC antibody
    see all


  • Vibratome (70 µm) sections of rat spinal cord immunostained with sheep polyclonal antiserum to CGRP at a dilution of 1:1000. Negative images of fluorescence detection procedure (Alexa488 conjugated secondary antibody). Micrograph courtesy of Professor Andrew Todd (university of Glasgow).


This product has been referenced in:
  • Wang D  et al. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron 98:90-108.e5 (2018). Read more (PubMed: 29576387) »
  • Tzabazis A  et al. Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders. Cephalalgia 36:943-50 (2016). Read more (PubMed: 26590611) »

See all 9 Publications for this product

Customer reviews and Q&As

I am very pleased to hear you would like to accept our offer and test ab22560 in mouse. This code will give you 1 free mouse before the expiration date. To redeem this offer, please submit an Abreview for mouse and include this code in the “Additional ...

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Thank you for your enquiry. I have examined each of the antibodies against one another with respect to your application of ICC in murine cells. ab10987 is a monoclonal antiserum that recognizes 10 amino acids in the C-terminus and recognizes hu...

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