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    cgrp-antibody-ab36001.pdf

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Anti-CGRP antibody (ab36001)

  • Datasheet
  • SDS
Reviews (11) Submit a question References (63)

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Key features and details

  • Goat polyclonal to CGRP
  • Reacts with: Mouse, Rat
  • Isotype: IgG

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Overview

  • Product name

    Anti-CGRP antibody
    See all CGRP primary antibodies
  • Description

    Goat polyclonal to CGRP
  • Host species

    Goat
  • Specificity

    Antibody is thought to react with whole molecule (1-37) and 23-37 fragment (C term). Specifically visualises CGRP in brain cells.
  • Species reactivity

    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Rat CGRP aa 23-37 (C terminal). Conjugated to gamma globulin.
    Sequence:

    VKDNFVPTNVGSEAF

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purified Ig by Ammonium Sulphate fractionation.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Neuropeptides
    • Hormones
    • Cardiovascular
    • Heart
    • Contractility
    • Inotropics
    • Cardiovascular
    • Vasculature
    • Vasodilation
    • Other

Associated products

  • Compatible Secondaries

    • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
    • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
  • Isotype control

    • Goat IgG, polyclonal - Isotype Control (ab37373)
  • Recombinant Protein

    • Recombinant Human CGRP protein (Tagged) (ab240778)

Applications

  • Application notes
    Is unsuitable for IHC-R.
  • Target

    • Relevance

      CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin.
    • Cellular localization

      Endoplasmic reticulum and Secreted
    • Database links

      • Entrez Gene: 116903 Mouse
      • Entrez Gene: 12310 Mouse
      • Entrez Gene: 171519 Rat
      • Entrez Gene: 24241 Rat
      • SwissProt: P70160 Mouse
      • SwissProt: Q99JA0 Mouse
      • SwissProt: P01256 Rat
      • SwissProt: P01257 Rat
      • Unigene: 273838 Mouse
      • Unigene: 4361 Mouse
      • Unigene: 88080 Rat
      • Unigene: 90085 Rat
      see all
    • Alternative names

      • Calcitonin/calcitonin related polypeptide alpha antibody
      • Alpha type CGRP antibody
      • Beta type CGRP antibody
      • CALC1 antibody
      • CALC2 antibody
      • CALCA antibody
      • CALCB antibody
      • Calcitonin 1 antibody
      • Calcitonin 2 antibody
      • Calcitonin gene related peptide I antibody
      • Calcitonin gene related peptide II antibody
      • Calcitonin related polypeptide alpha antibody
      • Calcitonin related polypeptide beta antibody
      • CGRP antibody
      • CGRP I antibody
      • CGRP II antibody
      • CGRP1 antibody
      • CGRP2 antibody
      • CT antibody
      • Katacalcin antibody
      • KC antibody
      see all

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (63)

    Publishing research using ab36001? Please let us know so that we can cite the reference in this datasheet.

    ab36001 has been referenced in 63 publications.

    • Taylor TS  et al. Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Physiol Rep 8:e14326 (2020). PubMed: 31960596
    • Liu T  et al. Local sympathetic innervations modulate the lung innate immune responses. Sci Adv 6:eaay1497 (2020). PubMed: 32426489
    • Kolter J  et al. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity 50:1482-1497.e7 (2019). PubMed: 31201094
    • Hardaway JA  et al. Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron 102:1037-1052.e7 (2019). PubMed: 31029403
    • Fetterly TL  et al. a2A-Adrenergic Receptor Activation Decreases Parabrachial Nucleus Excitatory Drive onto BNST CRF Neurons and Reduces Their Activity In Vivo. J Neurosci 39:472-484 (2019). PubMed: 30478032
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-10 of 11 Abreviews or Q&A

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-CGRP antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Rat Tissue sections (Brain (parabrachial nucleus)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citrate pH 6.4
    Permeabilization
    No
    Specification
    Brain (parabrachial nucleus
    Blocking step
    BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
    Fixative
    Formalin
    Read More

    Mr. Yazead Buhidma

    Verified customer

    Submitted Jan 22 2021

    Immunohistochemistry (Frozen sections) abreview for Anti-CGRP antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Rat Tissue sections (spinal cord cross section)
    Permeabilization
    Yes - 0,01% Triton-X 100
    Specification
    spinal cord cross section
    Blocking step
    BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 24°C
    Fixative
    Formaldehyde
    Read More

    Mr. Tamas Bellak

    Verified customer

    Submitted Nov 16 2020

    Immunohistochemistry (Frozen sections) abreview for Anti-CGRP antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Mouse Tissue sections (dorsal root ganglion)
    Permeabilization
    Yes - 0.3% PBST
    Specification
    dorsal root ganglion
    Fixative
    Paraformaldehyde
    Read More

    Abcam user community

    Verified customer

    Submitted Aug 09 2019

    IHC - Wholemount abreview for Anti-CGRP antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    IHC - Wholemount
    Sample
    Mouse Tissue (trachea)
    Specification
    trachea
    Read More

    Abcam user community

    Verified customer

    Submitted Dec 11 2018

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-CGRP antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Rat Tissue sections (Nerve (DRG))
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: pH 9.0 EDTA
    Permeabilization
    No
    Specification
    Nerve (DRG)
    Blocking step
    PB ab64226 as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: RT°C
    Fixative
    Formaldehyde
    Read More

    Abcam user community

    Verified customer

    Submitted Apr 30 2018

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-CGRP antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Mouse Tissue sections (Brain)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: pH 9.0 EDTA
    Permeabilization
    No
    Specification
    Brain
    Blocking step
    PB ab64226 as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: RT°C
    Fixative
    Formaldehyde
    Read More

    Abcam user community

    Verified customer

    Submitted Apr 30 2018

    Immunohistochemistry (PFA perfusion fixed frozen sections) abreview for Anti-CGRP antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (PFA perfusion fixed frozen sections)
    Sample
    Mouse Tissue sections (Dorsal Root Ganglia)
    Antigen retrieval step
    None
    Permeabilization
    Yes - 0.3% Triton X-100
    Specification
    Dorsal Root Ganglia
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 25°C
    Fixative
    Paraformaldehyde
    Read More

    Dr. Jean-Marc Guedon

    Verified customer

    Submitted Jun 03 2015

    Immunohistochemistry (Frozen sections) abreview for Anti-CGRP antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Rat Tissue sections (Spinal cord)
    Specification
    Spinal cord
    Fixative
    Formaldehyde
    Permeabilization
    No
    Blocking step
    BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
    Read More

    Mr. Carl Hobbs

    Verified customer

    Submitted Feb 25 2013

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-CGRP antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Rat Tissue sections (Spinal cord)
    Specification
    Spinal cord
    Fixative
    Formaldehyde
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citric acid
    Permeabilization
    No
    Blocking step
    BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
    Read More

    Mr. Carl Hobbs

    Verified customer

    Submitted Sep 06 2012

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-CGRP antibody

    Inconclusive
    Abreviews
    Abreviews
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Mouse Tissue sections (brain, spinal cord, muscle w/nerve)
    Specification
    brain, spinal cord, muscle w/nerve
    Fixative
    formalin, 10% neutral buffered
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citrate, pH6, microwave 2x, 5 min on high
    Permeabilization
    No
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: RT°C
    Read More

    Abcam user community

    Verified customer

    Submitted Mar 18 2010

    1-10 of 11 Abreviews or Q&A

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