Anti-CGRP antibody (ab36001)
Key features and details
- Goat polyclonal to CGRP
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-CGRP antibody
See all CGRP primary antibodies -
Description
Goat polyclonal to CGRP -
Host species
Goat -
Specificity
Antibody is thought to react with whole molecule (1-37) and 23-37 fragment (C term). Specifically visualises CGRP in brain cells. -
Species reactivity
Reacts with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Rat CGRP aa 23-37 (C terminal). Conjugated to gamma globulin.
Sequence:VKDNFVPTNVGSEAF
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein G purified -
Purification notes
Purified Ig by Ammonium Sulphate fractionation. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Application notes
Is unsuitable for IHC-R.
Target
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Relevance
CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. -
Cellular localization
Endoplasmic reticulum and Secreted -
Database links
- Entrez Gene: 116903 Mouse
- Entrez Gene: 12310 Mouse
- Entrez Gene: 171519 Rat
- Entrez Gene: 24241 Rat
- SwissProt: P70160 Mouse
- SwissProt: Q99JA0 Mouse
- SwissProt: P01256 Rat
- SwissProt: P01257 Rat
see all -
Alternative names
- Calcitonin/calcitonin related polypeptide alpha antibody
- Alpha type CGRP antibody
- Beta type CGRP antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (63)
ab36001 has been referenced in 63 publications.
- Taylor TS et al. Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Physiol Rep 8:e14326 (2020). PubMed: 31960596
- Liu T et al. Local sympathetic innervations modulate the lung innate immune responses. Sci Adv 6:eaay1497 (2020). PubMed: 32426489
- Kolter J et al. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity 50:1482-1497.e7 (2019). PubMed: 31201094
- Hardaway JA et al. Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron 102:1037-1052.e7 (2019). PubMed: 31029403
- Fetterly TL et al. a2A-Adrenergic Receptor Activation Decreases Parabrachial Nucleus Excitatory Drive onto BNST CRF Neurons and Reduces Their Activity In Vivo. J Neurosci 39:472-484 (2019). PubMed: 30478032
