Product nameCGRP (hu, Mod Asp3 to Pra)
DescriptionEndogenous vasodilatory neuropeptide.
- Calcitonin Gene Related Peptide
CGRP (hu, Mod Asp3 to Pra) ab146956 is a 37 amino acid neuroendocrine hormone that belongs to the calcitonin (CT) family. It is a vasodilator and plays an important role in neurogenic inflammation, and therefore has gained significant interest for the treatment of migraine. CGRP exerts effects through the CGRP receptor. To probe receptor binding, labelling with TAMRA azide, 5- isomer, Orange emitting fluorescent dye (ab146486), using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) to position 3 of human αCGRP, generates a potent fluorescent CGRP.
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Asp-3 = Pra; C-terminal amide; Disulfide bonds: 2-7)
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Soluble in water to 1mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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ab146956 has not yet been referenced specifically in any publications.