Chaetocin, histone lysine methyltransferase inhibitor (ab144534)

Overview

  • Product name
    Chaetocin, histone lysine methyltransferase inhibitor
  • Description
    Non-selective histone lysine methyltransferase inhibitor
  • Biological description
    Non-selective histone lysine methyltransferase inhibitor (IC50 values are 0.8, 2.5 and 3 μM for Suv39H1, G9a and DIM5 respectively). Competitive, selective thioredoxin substrate. Induces ROS generation and oxidative stress. Selectively induces apoptosis in cancer cell lines. Shows antiproliferative effects in vivo.
  • Purity
    > 98%
  • CAS Number
    28097-03-2
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-Octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
  • Molecular weight
    696.83
  • Molecular formula
    C30H28N6O6S4
  • PubChem identifier
    161591
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
  • Source

    Synthetic

References

This product has been referenced in:
  • Dixit D  et al. Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism. Cell Death Dis 5:e1212 (2014). Read more (PubMed: 24810048) »
  • Chiba T  et al. Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. Int J Cancer : (2014). Read more (PubMed: 24844570) »
  • Bernhard W  et al. The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response. FEBS Lett 585:3549-54 (2011). Read more (PubMed: 22020221) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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