Key features and details
- Non-selective histone lysine methyltransferase inhibitor
- CAS Number: 28097-03-2
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameChaetocin, histone lysine methyltransferase inhibitor
DescriptionNon-selective histone lysine methyltransferase inhibitor
Biological descriptionNon-selective histone lysine methyltransferase inhibitor (IC50 values are 0.8, 2.5 and 3 μM for Suv39H1, G9a and DIM5 respectively). Competitive, selective thioredoxin substrate. Induces ROS generation and oxidative stress. Selectively induces apoptosis in cancer cell lines. Shows antiproliferative effects in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144534 has been referenced in 1 publication.
- Nakajima NI et al. Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells. Oncol Rep 38:693-702 (2017). PubMed: 28677817