Overview

  • Product name

    Charybdotoxin, K+ channel blocker
  • Description

    K+ channel blocker
  • Biological description

    Blocks KCa1.1 (large conductance Ca2+ activated K+, Slo) channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels.
  • CAS Number

    95751-30-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Grissmer S  et al. Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol 45:1227-34 (1994). Read more (PubMed: 7517498) »
  • Gimenez-Gallego G  et al. Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci U S A 85:3329-33 (1988). Read more (PubMed: 2453055) »
  • Miller C  et al. Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature 313:316-8 (0). Read more (PubMed: 2578618) »
See all 4 Publications for this product

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