Key features and details
- Monocarboxylic acid transport inhibitor
- CAS Number: 28166-41-8
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameCHC, Monocarboxylic acid transport inhibitor
DescriptionMonocarboxylic acid transport inhibitor
- 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo. Decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of the DNA-methylating antitumor agent temozolomide (ab141055).
Chemical name2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146008 has been referenced in 1 publication.
- Hsu JW et al. Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes. Toxicol In Vitro 59:246-254 (2019). PubMed: 31009676