CHC, Monocarboxylic acid transport inhibitor (ab146008)

Overview

  • Product name

    CHC, Monocarboxylic acid transport inhibitor
  • Description

    Monocarboxylic acid transport inhibitor
  • Alternative names

    • 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
  • Biological description

    Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo. Decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of the DNA-methylating antitumor agent temozolomide (ab141055).

  • Purity

    > 98%
  • CAS Number

    28166-41-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
  • Molecular weight

    189.17
  • Molecular formula

    C10H7NO3
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Miranda-Gonçalves V  et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro Oncol 15:172-88 (2013). Read more (PubMed: 23258846) »
See 1 Publication for this product

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