Overview

  • Product name

  • Description

    Rabbit polyclonal to Chd1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment (GST-tag) corresponding to Human Chd1.
    Database link: O14646

  • Positive control

    • WB: HeLa nuclear extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab230388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 197 kDa.

Target

  • Function

    ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
  • Sequence similarities

    Belongs to the SNF2/RAD54 helicase family.
    Contains 2 chromo domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • Domain

    The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
  • Cellular localization

    Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATP dependent helicase CHD 1 antibody
    • ATP-dependent helicase CHD1 antibody
    • CHD 1 antibody
    • CHD-1 antibody
    • Chd1 antibody
    • CHD1_HUMAN antibody
    • Chromodomain helicase DNA binding protein 1 antibody
    • Chromodomain-helicase-DNA-binding protein 1 antibody
    • DKFZp686E2337 antibody
    • OTTHUMP00000222625 antibody
    see all

Images

  • Anti-Chd1 antibody (ab230388) at 1/500 dilution + HeLa (human epithelial cell line from cervix adenocarcinoma) nuclear extract at 20 µg

    Predicted band size: 197 kDa

References

ab230388 has not yet been referenced specifically in any publications.

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