DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
Frequently overexpressed in hepatomacellular carcinomas.
Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 Macro domain.
The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.