Overview

  • Product name

    Cheirolin, Nrf2 inducer
  • Description

    Potent Nrf2 inducer
  • Biological description

    Potent Nrf2 inducer. Sulfonyl analogue. Increases heme oxygenase 1 and γ-glutamylcysteine synthetase mRNA and protein levels with similar potency to Iberverin (ab142890) Iberin (ab141944).
  • Purity

    > 97%
  • CAS Number

    505-34-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Isothiocyanato-3-methylsulfonylpropane
  • Molecular weight

    179.26
  • Molecular formula

    C5H9NO2S2
  • PubChem identifier

    10454
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CS(=O)(=O)CCCN=C=S
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ernst IM  et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res 70:155-62 (2013). Read more (PubMed: 23403058) »
  • Kim SH & Singh SV D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. Mol Cancer Ther 8:1946-54 (2009). Read more (PubMed: 19584240) »
  • Munday R & Munday CM Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem 52:1867-71 (2004). Read more (PubMed: 15053522) »

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