Overview

  • Product name

    Chenodeoxycholic acid, bile acids component
  • Description

    Major bile acids component
  • Biological description

    Major bile acids component. Various pharmacological effects. Induces Nrf2 target genes, especially the rate-limiting enzyme in glutathione biosynthesis (GCLM), the glutamate cysteine ligase catalytic subunit (GCLC), and thioredoxin reductase 1.
  • Purity

    > 98%
  • CAS Number

    474-25-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3α,5β,7α)-3,7-Dihydroxycholan-24-oic acid
  • Molecular weight

    392.57
  • Molecular formula

    C24H40O4
  • PubChem identifier

    10133
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tan KP  et al. Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress. Mol Pharmacol 72:1380-90 (2007). Read more (PubMed: 17724089) »
  • Rizzo G  et al. Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Curr Drug Targets Immune Endocr Metabol Disord 5:289-303 (2005). Read more (PubMed: 16178789) »
  • Tint GS  et al. Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism. Gastroenterology 91:1007-18 (1986). Read more (PubMed: 3527851) »

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