Key features and details
- Potent HIF signaling inhibitor
- CAS Number: 1403-36-7
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Chaetomium sp.
Product nameChetomin, HIF signaling inhibitor
DescriptionPotent HIF signaling inhibitor
Biological descriptionPotent HIF signaling inhibitor. Reduces CA9 and VEGF expression in hypoxic cells (IC50 = 10 nM, secreted VEGF, Hep38 cells). Shows antibacterial and antifungal effects. Shows antitumor effects in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144222 has been referenced in 1 publication.
- Cabezas-Cruz A et al. Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis. Front Cell Infect Microbiol 7:23 (2017). PubMed: 28229048