Overview

  • Product name

    Chetomin, HIF signaling inhibitor
  • Description

    Potent HIF signaling inhibitor
  • Biological description

    Potent HIF signaling inhibitor. Reduces CA9 and VEGF expression in hypoxic cells (IC50 = 10 nM, secreted VEGF, Hep38 cells). Shows antibacterial and antifungal effects. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    1403-36-7
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    710.87
  • Molecular formula

    C31H30N6O6S4
  • PubChem identifier

    10417379
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C(=O)[C@]2(N(C(=O)[C@@]1(SS2)CC3=CN(C4=CC=CC=C43)[C@]56C[C@]78C(=O)N([C@](C(=O)N7[C@H]5NC9=CC=CC=C69)(SS8)CO)C)C)CO
  • Source

    Chaetomium sp.

  • Research areas

Associated products

References

This product has been referenced in:

  • Wu Q  et al. Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models. Nanoscale 6:11940-52 (2014). Read more (PubMed: 25175172) »
  • Misra RM  et al. Vasculogenic mimicry of HT1080 tumour cells in vivo: critical role of HIF-1a-neuropilin-1 axis. PLoS One 7:e50153 (2012). Read more (PubMed: 23185562) »
  • Staab A  et al. Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 7:213 (2007). Read more (PubMed: 17999771) »
See 1 Publication for this product

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