Overview

  • Product name

    CHIR 98014, ATP-competitive GSK3 inhibitor
  • Description

    Potent, selective ATP-competitive GSK3 inhibitor
  • Biological description

    Potent, selective ATP-competitive GSK3 inhibitor (IC50 values are 0.58 and 0.65 nM for GSKα and GSKβ respectively). Potently activates the Wnt/beta-catenin signaling pathway. Also supplied as solution (ab146633).
  • Purity

    > 98%
  • CAS Number

    556813-39-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
  • Molecular weight

    486.32
  • Molecular formula

    C20H17Cl2N9O2
  • PubChem identifier

    53396311
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Naujok O  et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes 7:273 (2014). Read more (PubMed: 24779365) »
  • Selenica ML  et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol 152:959-79 (2007). Read more (PubMed: 17906685) »
  • Ring DB  et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52:588-95 (2003). Read more (PubMed: 12606497) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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