Key features and details
- Potent, selective ATP-competitive GSK3 inhibitor
- CAS Number: 556813-39-9
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Product nameCHIR 98014, ATP-competitive GSK3 inhibitor
DescriptionPotent, selective ATP-competitive GSK3 inhibitor
Biological descriptionPotent, selective ATP-competitive GSK3 inhibitor (IC50 values are 0.58 and 0.65 nM for GSKα and GSKβ respectively). Potently activates the Wnt/beta-catenin signaling pathway. Also supplied as solution (ab146633).
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146582 has been referenced in 1 publication.
- Inami Y et al. Inhibition of glycogen synthase kinase-3 reduces extension of the axonal leading process by destabilizing microtubules in cerebellar granule neurons. Brain Res 1690:51-60 (2018). PubMed: 29653082