CHIR99021, GSK3 inhibitor (ab120890)
- Datasheet
- References (3)
Overview
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Product name
CHIR99021, GSK3 inhibitor -
Description
Potent, highly selective GSK3 inhibitor -
Purity
> 98% -
CAS Number
252917-06-9 -
Chemical structure
Properties
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Chemical name
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile -
Molecular weight
465.34 -
Molecular formula
C22H18Cl2N8 -
PubChem identifier
9956119 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Ye S et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One 7:e35892 (2012). Read more (PubMed: 22540008) »
- Li W et al. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27:2992-3000 (2009). Read more (PubMed: 19839055) »
- Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52:588-95 (2003). Read more (PubMed: 12606497) »
