Product nameAnti-Chlamydia trachomatis MOMP antibody [BIOD166]
See all Chlamydia trachomatis MOMP primary antibodies
DescriptionMouse monoclonal [BIOD166] to Chlamydia trachomatis MOMP
SpecificityAb20881 is specific for major outer membrane protein (MOMP) of Chlamydia trachomatis. No reactivity with C. pneumoniae.
Tested applicationsSuitable for: ICC/IF, WB, ELISAmore details
Species reactivityReacts with: Chlamydia trachomatis
Does not react with: Chlamydia pneumoniae
Chlamydia trachomatis elementary bodies.
Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab20881 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration. PubMed: 21628561|
|WB||Use at an assay dependent concentration. PubMed: 21628561|
|ELISA||1/20 - 1/200.|
RelevanceChlamydia is caused by the bacterium Chlamydia trachomatis. The intracytoplasmic inclusions caused by the bacterium are draped around the infected cell's nucleus. Chlamydia trachomatis is an intracellular organism that has a genome size of approximately 500-1000 kilobases and contains both RNA and DNA. The organism is also extremely temperature sensitive and must be refrigerated at 4°C as soon as a sample is obtained. Colonization of Chlamydia begins with attachment to sialic acid receptors on the eye, throat or genitalia. It persists at body sites that are inaccessible to phagocytes, T cells, and B cells. It also exists as 15 different serotypes. These serotypes cause four major diseases in humans: endemic trachoma (caused by serotypes A and C), sexually transmitted disease and inclusion conjunctivitis (caused by serotypes D and K), and lymphogranuloma venereum (caused by serotypes L1, L2, and L3). Studies reveal that Chlamydia, because of its cell wall, is able to inhibit phagolysosome fusion in phagocytes. The cell wall is proposed to be Gram negative in that it contains an outer lipopolysaccharide membrane, but it lacks peptidoglycan in its cell wall. This lack of peptidoglycan is shown by the inability to detect muramic acid and antibodies directed against it. It may, however, contain a carboxylated sugar other than muramic acid. The proposed structure consists of a major outer membrane protein cross linked with disulfide bonds. It also contains cysteine rich proteins (CRP) that may be the functional equivalent to peptidoglycan. This unique structure allows for intracellular division and extracellular survival (Hatch 1996). Chlamydia usually infects the cervix and fallopian tubes of women and the urethra of men. Chlamydial infections are believed to be one of the most common of all STDs. It is generally thought that in a population of 15 million, there are up to 300,000 cases of chlamydia each year. Thus, there are many undiagnosed cases of chlamydia in the community. It has been estimated that the true prevalence of chlamydia in the sexually active population may be in the order of 5% to 10%. Chlamydia is one of the leading causes of blindness in underdeveloped countries.
Cellular localizationOuter membrane; multi pass membrane protein.
- Entrez Gene: 3688076 Chlamydia trachomatis
- Entrez Gene: 884473 Chlamydia trachomatis
- SwissProt: P06597 Chlamydia trachomatis
- SwissProt: P08780 Chlamydia trachomatis
- SwissProt: P13467 Chlamydia trachomatis
- SwissProt: P16155 Chlamydia trachomatis
- SwissProt: P17451 Chlamydia trachomatis
- SwissProt: P19542 Chlamydia trachomatis
- Major Outer Membrane Protein antibody
- MOMP antibody
- omp1 antibody
This product has been referenced in:
- Vouga M et al. Simkania negevensis may produce long-lasting infections in human pneumocytes and endometrial cells. Pathog Dis 75:N/A (2017). Read more (PubMed: 28087650) »
- Vouga M et al. Simkania negevensis, an Example of the Diversity of the Antimicrobial Susceptibility Pattern among Chlamydiales. Antimicrob Agents Chemother 61:N/A (2017). Read more (PubMed: 28559259) »