Chlorhexidine hydrochloride, Matrix metalloproteinase (MMP) inhibitor (ab145702)

Overview

  • Product name

    Chlorhexidine hydrochloride, Matrix metalloproteinase (MMP) inhibitor
  • Description

    Antiseptic; Matrix metalloproteinase inhibitor.
  • Alternative names

    • 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane
    • Chlorhexidine dihydrochloride
    • CHX HCl
    • Lisium
    • NSC-185
    see all
  • Biological description

    Antiseptic effective against a wide variety of gram-negative and gram-positive organisms, used in antiseptics and dental products. Bacteriostatic and bactericidal activity due to outer bacterial membrane disruption. Directly inhibits Matrix metalloproteinases MMP-2, MMP-8, and MMP-9 possibly via a cation-chelating mechanism.

  • Purity

    > 99%
  • CAS Number

    3697-42-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N1,N14-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide hydrochloride
  • Molecular weight

    578.37
  • Molecular formula

    C22H30Cl2N10.2HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Donskey CJ & Deshpande A Effect of chlorhexidine bathing in preventing infections and reducing skin burden and environmental contamination: A review of the literature. Am J Infect Control 44:e17-21 (2016). Read more (PubMed: 27131130) »
  • Kato MT  et al. Gels containing MMP inhibitors prevent dental erosion in situ. J Dent Res 89:468-72 (2010). Read more (PubMed: 20200409) »
  • Gendron R  et al. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol 6:437-9 (1999). Read more (PubMed: 10225852) »

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