Product nameChlorhexidine hydrochloride, Matrix metalloproteinase (MMP) inhibitor
DescriptionAntiseptic; Matrix metalloproteinase inhibitor.
- Chlorhexidine dihydrochloride
- CHX HCl
Antiseptic effective against a wide variety of gram-negative and gram-positive organisms, used in antiseptics and dental products. Bacteriostatic and bactericidal activity due to outer bacterial membrane disruption. Directly inhibits Matrix metalloproteinases MMP-2, MMP-8, and MMP-9 possibly via a cation-chelating mechanism.
Chemical nameN1,N14-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Donskey CJ & Deshpande A Effect of chlorhexidine bathing in preventing infections and reducing skin burden and environmental contamination: A review of the literature. Am J Infect Control 44:e17-21 (2016). Read more (PubMed: 27131130) »
- Kato MT et al. Gels containing MMP inhibitors prevent dental erosion in situ. J Dent Res 89:468-72 (2010). Read more (PubMed: 20200409) »
- Gendron R et al. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol 6:437-9 (1999). Read more (PubMed: 10225852) »