Chlorocresol, Ryanodine receptor activator (ab145836)

Overview

  • Product name

    Chlorocresol, Ryanodine receptor activator
  • Description

    Ryanodine receptor activator
  • Alternative names

    • 4-chloro-3-methylphenol
    • 4-Chloro-m-cresol
    • 4-CmC
    • p-chloro-m-cresol
    • p-Chlorocresol
    • PCMC
    • Phenol, 4-chloro-3-methyl-
    • Preventol CMK
    see all
  • Biological description

    Chlorinated phenol used as an antiseptic and preservative. Activates ryanodine receptor-mediated Ca2+ release.

  • Purity

    > 99%
  • CAS Number

    59-50-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Chloro-3-methylphenol
  • Molecular weight

    142.58
  • Molecular formula

    C7H7ClO
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Gschwend MH  et al. A transient and a persistent calcium release are induced by chlorocresol in cultivated mouse myotubes. Pflugers Arch 438:101-6 (1999). Read more (PubMed: 10370093) »
  • Tegazzin V  et al. Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel. Anesthesiology 84:1380-5 (1996). Read more (PubMed: 8669679) »
  • Zorzato F  et al. Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release. Mol Pharmacol 44:1192-201 (1993). Read more (PubMed: 8264556) »

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