Product nameChlorocresol, Ryanodine receptor activator
DescriptionRyanodine receptor activator
Chlorinated phenol used as an antiseptic and preservative. Activates ryanodine receptor-mediated Ca2+ release.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Gschwend MH et al. A transient and a persistent calcium release are induced by chlorocresol in cultivated mouse myotubes. Pflugers Arch 438:101-6 (1999). Read more (PubMed: 10370093) »
- Tegazzin V et al. Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel. Anesthesiology 84:1380-5 (1996). Read more (PubMed: 8669679) »
- Zorzato F et al. Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release. Mol Pharmacol 44:1192-201 (1993). Read more (PubMed: 8264556) »