Overview

  • Product name

    Chloroquine diphosphate, apoptosis and autophagy inhibitor
  • Description

    Antimalarial; apoptosis and autophagy inhibitor
  • Biological description

    Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.
  • Purity

    > 98%
  • CAS Number

    50-63-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine diphosphate
  • Molecular weight

    515.87
  • Molecular formula

    C18H26ClN3.2H3PO4
  • PubChem identifier

    64927
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jiang PD  et al. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed Pharmacother 64:609-14 (2010). Read more (PubMed: 20888174) »
  • Rajapakse CS  et al. Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine. Inorg Chem 48:1122-31 (2009). Read more (PubMed: 19119867) »
  • Fan C  et al. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells. Bioorg Med Chem 14:3218-22 (2006). Read more (PubMed: 16413786) »
See 1 Publication for this product

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