Overview

  • Product name

    Chlorothiazide, carbonic anhydrase inhibitor
  • Description

    diuretic and antihypertensive. Carbonic anhydrase inhibitor.
  • Biological description

    Carbonic anhydrase inhibitor. Inhibits Na+/Cl- reabsorption from the distal convoluted tubules. Selectively transported by ABCG2 (Km = 335 μM). Shows diuretic and antihypertensive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    58-94-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • Molecular weight

    295.72
  • Molecular formula

    C7H6ClN3O4S2
  • PubChem identifier

    2720
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C=C2C(=C1)N=CNS2(=O)=O)S(N)(=O)=O)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Juhász V  et al. Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3. J Pharm Sci 102:1683-7 (2013). Read more (PubMed: 23457060) »
  • Beéry E  et al. ABCG2 modulates chlorothiazide permeability--in vitro-characterization of its interactions. Drug Metab Pharmacokinet 27:349-53 (2012). Read more (PubMed: 22790065) »
  • Furtado D Effect of chlorothiazide and furosemide diuresis on in vivo growth of Staphylococcus aureus in kidneys of mice. Invest Urol 13:414-7 (1976). Read more (PubMed: 1270236) »

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