Chlorprothixene, dopamine, 5-HT and H1 receptor antagonist (ab143077)

Overview

  • Product name

    Chlorprothixene, dopamine, 5-HT and H1 receptor antagonist
  • Description

    Potent, non-selective dopamine, 5-HT and H1 receptor antagonist
  • Biological description

    Potent, non-selective dopamine, 5-HT and H1 receptor antagonist (Ki values are 18, 3, 5, 9, 9, 3, 6 and 4 nM for D1, D2, D3, D5, 5-HT2, 5-HT6, 5-HT7 and H1 receptors respectively). α1-adrenoceptor and muscarinic receptor antagonist. Induces spinal anesthesia when administered intrathecally. Shows antipsychotic effects and in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    113-59-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Megens AA  et al. Differential interaction of neuroleptics with apomorphine-induced behavior in rats as a function of changing levels of dopamine receptor stimulation. J Pharmacol Exp Ther 347:681-96 (2013). Read more (PubMed: 24071734) »
  • Schulz SB  et al. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167:1480-91 (2012). Read more (PubMed: 22817643) »
  • Chen YW  et al. Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats. Eur J Pharmacol 693:31-6 (2012). Read more (PubMed: 22926199) »

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