Chlorzoxazone, SK-type potassium channel modulator (ab145779)

Overview

  • Product name

    Chlorzoxazone, SK-type potassium channel modulator
  • Description

    Centrally acting skeletal muscle relaxant; SK-type potassium channel modulator.
  • Alternative names

    • 5-Chloro-2(3H)-benzoxazolone
    • 5-Chloro-2- benzoxazolinone
    • 5-Chloro-2-hydroxybenzoxazole
    • Lorzone
    • Muscol
    • Paraflex
    see all
  • Biological description

    Benzoxazolone derivative. Centrally acting skeletal muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. Displays sedative properties. SK-type potassium channel modulator. Converted to to 6-hydroxy chlorzoxazone mainly by cytochrome P450 isoform CYP2E1. Used as a probe for CYP2E1 activity in microsomes from various sources.

  • Purity

    > 99%
  • CAS Number

    95-25-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Chloro-2(3H)-benzoxazolone
  • Molecular weight

    169.57
  • Molecular formula

    C7H4ClNO2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Hopf FW  et al. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry 69:618-24 (2011). Read more (PubMed: 21195386) »
  • Cao Y  et al. Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther 296:683-9 (2001). Read more (PubMed: 11181893) »
  • Frye RF  et al. Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure. J Clin Pharmacol 38:82-9 (1998). Read more (PubMed: 9597564) »
  • Lucas D  et al. Chlorzoxazone: an in vitro and in vivo substrate probe for liver CYP2E1. Methods Enzymol 272:115-23 (1996). Read more (PubMed: 8791768) »

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