Key features and details
- Goat polyclonal to CHM - N-terminal
- Suitable for: WB
- Reacts with: Mouse, Rat, Dog, Human, Monkey
- Isotype: IgG
Product nameAnti-CHM antibody - N-terminal
See all CHM primary antibodies
DescriptionGoat polyclonal to CHM - N-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Dog, Human, Monkey
- HEK293 cell lysates transfected with VS-REP1 or AtT20
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 20% Glycerol, 79% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab192454 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 72 kDa.|
FunctionBinds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Involvement in diseaseDefects in CHM are the cause of choroideremia (CHM) [MIM:303100]. An X-linked recessive disease characterized by a slowly progressive degeneration of the choroid, photoreceptors, and retinal pigment epithelium. Affected males develop night blindness in their teenage years followed by loss of peripheral vision and complete blindness at middle age. Carrier females are generally asymptomatic but funduscopic examination often shows patchy areas of chorioretinal atrophy.
Sequence similaritiesBelongs to the Rab GDI family.
- Information by UniProt
- CHM antibody
- Chm antibody
- Choroideraemia protein antibody
All lanes : Anti-CHM antibody - N-terminal (ab192454) at 1/1000 dilution
Lane 1 : HEK293 cells transfected with VS-REP1
Lane 2 : HEK293 cells transfected with AtT20
Lysates/proteins at 100 µg per lane.
All lanes : Rabbit polyclonal anti goat IgG (HRP) at 1/10000 dilution
Predicted band size: 72 kDa
ab192454 has not yet been referenced specifically in any publications.