Overview

  • Product name

    CHM1, Antitumor agent
  • Description

    Potent antitumor agent
  • Biological description

    Potent antitumor agent. Antiproliferative, anti-angiogenic and anti-apoptotic in a dose dependent manner. Reduces cell viability (IC50 = 0.13 - 8.2 μM) and tumor invasion. Active in vitro and in vivo. Increases expression of DR5, TRIAL, p53. Reduces tumor polymerisation and caspase activation.
  • Purity

    > 99%
  • CAS Number

    154554-41-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
  • Molecular weight

    283.26
  • Molecular formula

    C16H10FNO3
  • PubChem identifier

    375860
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM (with warming) and in ethanol to 5 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Fc4ccccc4C=2Nc1cc3OCOc3cc1C(=O)C=2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lee JC  et al. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. Eur J Pharmacol 670:96-104 (2011). Read more (PubMed: 21907193) »
  • Tsai AC  et al. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem 285:5497-506 (2010). Read more (PubMed: 20007968) »
  • Wang SW  et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther 7:350-60 (2008). Read more (PubMed: 18281518) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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