Recombinant Anti-CHMP1a antibody [EPR11938(B)] (ab167412)


  • Product name

    Anti-CHMP1a antibody [EPR11938(B)]
    See all CHMP1a primary antibodies
  • Description

    Rabbit monoclonal [EPR11938(B)] to CHMP1a
  • Host species

  • Tested applications

    Suitable for: WB, ICC/IFmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide,corresponding to residues in Human CHMP1a (UniProt: Q9HD42).

  • Positive control

    • 293T, HeLa, LNCaP, C6, RAW264.7 and PC12 cell lysates; HeLa cells.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab167412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 22 kDa.
ICC/IF 1/250 - 1/500.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function

      Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
    • Tissue specificity

      Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.
    • Sequence similarities

      Belongs to the SNF7 family.
    • Cellular localization

      Cytoplasm. Endosome membrane. Nucleus matrix. The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
    • Information by UniProt
    • Database links

    • Alternative names

      • Charged multivesicular body protein 1a antibody
      • CHM1A_HUMAN antibody
      • CHMP1a antibody
      • Chromatin modifying protein 1a antibody
      • Chromatin-modifying protein 1a antibody
      • hVps46 1 antibody
      • hVps46-1 antibody
      • KIAA0047 antibody
      • Metalloprotease 1 antibody
      • PCOLN3 antibody
      • Procollagen (type III) N endopeptidase antibody
      • PRSM1 antibody
      • Vacuolar protein sorting 46 1 antibody
      • Vacuolar protein sorting-associated protein 46-1 antibody
      • Vps46 1 antibody
      • Vps46-1 antibody
      see all


    • All lanes : Anti-CHMP1a antibody [EPR11938(B)] (ab167412) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : LNCaP cell lysate
      Lane 4 : C6 cell lysate
      Lane 5 : RAW264.7 cell lysate
      Lane 6 : PC12 cell lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

      Predicted band size: 22 kDa

    • Immunofluorescent analysis of HeLa cells labeling CHMP1a with ab167412 at 1/250 dilution. DAPI nuclear staining is shown in blue.


    ab167412 has not yet been referenced specifically in any publications.

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