Overview

  • Product name

  • Description

    Rabbit polyclonal to CHN 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Human CHN 1 aa 1-200.
    Database link: P15882

  • Positive control

    • WB: HEK-293T, MCF7, HeLa and Jurkat whole cell lysates. IHC-P: Human colon cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab229929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 53 kDa (predicted molecular weight: 54, 39, 51 kDa).
IHC-P 1/20 - 1/200.

Target

  • Function

    GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms.
  • Tissue specificity

    In neurons in brain regions that are involved in learning and memory processes.
  • Involvement in disease

    Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
  • Sequence similarities

    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Rho-GAP domain.
    Contains 1 SH2 domain.
  • Developmental stage

    Increases in amount during brain development coincident with synaptogenesis.
  • Information by UniProt
  • Database links

  • Alternative names

    • A-chimaerin antibody
    • Alpha-chimerin antibody
    • ARHGAP2 antibody
    • CHIN_HUMAN antibody
    • CHN antibody
    • Chn1 antibody
    • N chimaerin antibody
    • N chimerin antibody
    • N-chimaerin antibody
    • N-chimerin antibody
    • NC antibody
    • Rho GTPase-activating protein 2 antibody
    • RHOGAP2 antibody
    see all

Images

  • All lanes : Anti-CHN 1 antibody (ab229929) at 1/1000 dilution

    Lane 1 : HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
    Lane 2 : MCF7 (Human breast adenocarcinoma cell line) whole cell lysate
    Lane 3 : Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell lysate
    Lane 4 : HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate

    Secondary
    All lanes : Goat polyclonal to Rabbit IgG at 1/10000 dilution

    Developed using the ECL technique.

    Predicted band size: 54, 39, 51 kDa

  • Paraffin-embedded human colon cancer tissue stained for CHN 1 with ab229929 at a 1/100 dilution in immunohistochemical analysis.

References

ab229929 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229929.
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