Overview

  • Product name

    Cholecalciferol (Vitamin D3), VDR activator
  • Description

    VDR activator
  • Alternative names

    • Vitamin D3
  • Biological description

    VDR activator. Induces cell differentiation and shows antiproliferative effects. Metabolic calcifediol (ab142766) precursor. Shows antioxidant and anti-inflammatory effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    67-97-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
  • Molecular weight

    384.64
  • Molecular formula

    C27H44O
  • PubChem identifier

    5280795
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wang Q  et al. Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4. J Biol Chem 289:11681-94 (2014). Read more (PubMed: 24619416) »
  • Schmidt N  et al. Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice. J Nutr 144:638-46 (2014). Read more (PubMed: 24647396) »
  • Erbas O  et al. Cholecalciferol (vitamin D 3) improves cognitive dysfunction and reduces inflammation in a rat fatty liver model of metabolic syndrome. Life Sci 103:68-72 (2014). Read more (PubMed: 24727236) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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