Cholic acid, non-denaturing ionic detergent (ab146304)

Overview

  • Product name

    Cholic acid, non-denaturing ionic detergent
  • Description

    Non-denaturing ionic detergent used for extraction of membrane proteins.
  • Alternative names

    • Cholalic Acid
    • Cholalin
    • Cholanic acid
  • Biological description

    Non-denaturing ionic detergent used for extraction of membrane proteins. Major primary bile acid produced in the liver and usually conjugated with glycine or taurine to form bile salts. Facilitates fat absorption and cholesterol excretion.


     

  • Purity

    > 98%
  • CAS Number

    81-25-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid
  • Molecular weight

    408.60
  • Molecular formula

    C24H40O5
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Reich M  et al. TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro. Gut 65:487-501 (2016). Read more (PubMed: 26420419) »
  • Blazquez AG  et al. Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol 81:273-83 (2012). Read more (PubMed: 22096226) »
  • Huang J  et al. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal 55:1111-9 (2011). Read more (PubMed: 21530128) »

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