Key features and details
- Rabbit polyclonal to Choline Acetyltransferase
- Suitable for: IHC-FrFl
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-Choline Acetyltransferase antibody
See all Choline Acetyltransferase primary antibodies
DescriptionRabbit polyclonal to Choline Acetyltransferase
SpecificityExtensive immunohistochemistry indicates localisation to cholinergic nervous system only. Will stain cholinergic neurons in rat central and peripheral nervous systems.
Tested applicationsSuitable for: IHC-FrFlmore details
Species reactivityReacts with: Rat
Predicted to work with: Chicken, Human, Pig, Non human primatesDoes not react with: Sheep
General notesThis antibody appears to have identical characteristics to those described by Benecke et al (1993). The antigen is the same. It is an excellent reagent for immunohistochemistry for both peripheral and central nervous system, staining both cell bodies and nerve terminals.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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The Abpromise guarantee
Our Abpromise guarantee covers the use of ab6168 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
FunctionCatalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Involvement in diseaseMyasthenic syndrome, congenital, 6, presynaptic
Sequence similaritiesBelongs to the carnitine/choline acetyltransferase family.
- Information by UniProt
- Acetyl CoA choline O acetyltransferase antibody
- Acetyl CoA:choline O acetyltransferase antibody
- ChAT antibody
ab6168 has been referenced in 10 publications.
- Kannan A et al. ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy. Brain 143:69-93 (2020). PubMed: 31828288
- Zhu Q et al. Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease. Mol Med Rep 21:1172-1180 (2020). PubMed: 31922229
- Tarafder S et al. A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury. Theranostics 9:4241-4254 (2019). PubMed: 31281545
- Bagher Z et al. Differentiation of neural crest stem cells from nasal mucosa into motor neuron-like cells. J Chem Neuroanat 92:35-40 (2018). ICC/IF . PubMed: 29807106
- Chen X et al. Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury. Adv Healthc Mater 7:e1800315 (2018). PubMed: 29920990
- Genabai NK et al. Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. Sci Rep 7:8295 (2017). PubMed: 28811488
- Genabai NK et al. Genetic inhibition of JNK3 ameliorates spinal muscular atrophy. Hum Mol Genet 24:6986-7004 (2015). PubMed: 26423457
- Tu JL et al. APOE 4 polymorphism results in early cognitive deficits in an EAE model. Biochem Biophys Res Commun 384:466-70 (2009). WB, IHC-P ; Mouse . PubMed: 19422789
- Masliukov PM & Timmermans JP Immunocytochemical properties of stellate ganglion neurons during early postnatal development. Histochem Cell Biol 122:201-9 (2004). PubMed: 15338227
- Bao F & Liu D Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits. Neuroscience 115:839-49 (2002). PubMed: 12435422