Anti-Choline Acetyltransferase antibody (ab6168)
Key features and details
- Rabbit polyclonal to Choline Acetyltransferase
- Suitable for: IHC-FrFl
- Reacts with: Rat
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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Overview
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Product name
Anti-Choline Acetyltransferase antibody
See all Choline Acetyltransferase primary antibodies -
Description
Rabbit polyclonal to Choline Acetyltransferase -
Host species
Rabbit -
Specificity
Extensive immunohistochemistry indicates localisation to cholinergic nervous system only. Will stain cholinergic neurons in rat central and peripheral nervous systems. -
Tested applications
Suitable for: IHC-FrFlmore details -
Species reactivity
Reacts with: Rat
Predicted to work with: Chicken, Human, Pig, Non human primatesDoes not react with: Sheep -
Immunogen
Synthetic peptide:
H-GLFSSYRLPGHTQDTLVAQKSS
conjugated to KLH by a Glutaraldehyde linker, corresponding to amino acids 168-189 of Choline Acetyltransferase. -
General notes
This antibody appears to have identical characteristics to those described by Benecke et al (1993). The antigen is the same. It is an excellent reagent for immunohistochemistry for both peripheral and central nervous system, staining both cell bodies and nerve terminals.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab6168 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-FrFl |
Use at an assay dependent concentration.
|
Notes |
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IHC-FrFl
Use at an assay dependent concentration. |
Target
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Function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. -
Involvement in disease
Myasthenic syndrome, congenital, 6, presynaptic -
Sequence similarities
Belongs to the carnitine/choline acetyltransferase family. - Information by UniProt
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Database links
- Entrez Gene: 1103 Human
- Entrez Gene: 396896 Pig
- Entrez Gene: 290567 Rat
- Omim: 118490 Human
- SwissProt: P28329 Human
- SwissProt: P13222 Pig
- SwissProt: P32738 Rat
- Unigene: 302002 Human
see all -
Alternative names
- Acetyl CoA choline O acetyltransferase antibody
- Acetyl CoA:choline O acetyltransferase antibody
- ChAT antibody
see all
Images
Datasheets and documents
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Datasheet download
References (13)
ab6168 has been referenced in 13 publications.
- Liu Z et al. Activation of Neural Modeling-Related Genes in the Heart of Mice after Gamma Irradiation. Comput Math Methods Med 2021:8522417 (2021). PubMed: 35003326
- Li L et al. Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice via Basal Forebrain-Hippocampus Cholinergic Neural Circuit. Front Aging Neurosci 13:770948 (2021). PubMed: 35185516
- Zhu Q et al. Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease. Mol Med Rep 21:1172-1180 (2020). PubMed: 31922229
- Xiao Q et al. A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety. Mol Psychiatry N/A:N/A (2020). PubMed: 32555286
- Kannan A et al. ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy. Brain 143:69-93 (2020). PubMed: 31828288