Overview

  • Product name

  • Description

    Rabbit polyclonal to CHRDL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human CHRDL1 (internal sequence). The exact sequence is proprietary.
    Database link: Q9BU40

  • Positive control

    • WB: Rat brain tissue extract. IHC-P: Mouse kidney and hind brain tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab227473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 51 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.
  • Tissue specificity

    Expressed in retinal pericytes.
  • Sequence similarities

    Contains 3 VWFC domains.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • CHL antibody
    • chordin like 1 antibody
    • Chordin-like protein 1 antibody
    • CHRDL1 antibody
    • CRDL1_HUMAN antibody
    • dA141H5.1 antibody
    • neuralin 1 antibody
    • Neuralin-1 antibody
    • Neurogenesin-1 antibody
    • NRLN1 antibody
    • Ventroptin antibody
    • VOPT antibody
    see all

Images

  • Anti-CHRDL1 antibody (ab227473) at 1/500 dilution + Rat brain tissue extract at 50 µg

    Developed using the ECL technique.

    Predicted band size: 51 kDa



    10% SDS-PAGE

  • Paraffin-embedded mouse hind brain tissue stained for CHRDL1 with ab227473 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded mouse kidney tissue stained for CHRDL1 with ab227473 at 1/500 dilution in immunohistochemical analysis.

References

ab227473 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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