Anti-Chromogranin A antibody (ab15160)

Rabbit polyclonal Chromogranin A antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Human, Monkey. Cited in 81 publication(s). Independently reviewed in 24 review(s).

Publishing research using ab15160? Please let us know so that we can cite the reference in this datasheet.

ab15160 has been referenced in 94 publications.

  • Wartenberg H  et al. The Origin of a New Progenitor Stem Cell Group in Human Development. Adv Anat Embryol Cell Biol 230:1-70 (2019). PubMed: 30543033
  • Guo H  et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun 10:278 (2019). PubMed: 30655535
  • Clark DPQ  et al. Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk. Neurochem Res N/A:N/A (2019). PubMed: 30661228
  • Cai Y  et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov 5:7 (2019). PubMed: 30701081
  • Larraufie P  et al. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Rep 26:1399-1408.e6 (2019). PubMed: 30726726
  • Konno T  et al. Role of lysophosphatidic acid in proliferation and differentiation of intestinal epithelial cells. PLoS One 14:e0215255 (2019). PubMed: 31017922
  • Zha JM  et al. Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. Cell Mol Gastroenterol Hepatol 7:255-274 (2019). PubMed: 30686779
  • Antas P  et al. SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating ß-Catenin Nuclear Localization. Cell Rep 26:2266-2273.e4 (2019). PubMed: 30811977
  • Owen RP  et al. Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands. Nat Commun 9:4261 (2018). PubMed: 30323168
  • Jijon HB  et al. Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Mucosal Immunol 11:703-715 (2018). PubMed: 29139475
  • Sznurkowska MK  et al. Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development. Dev Cell 46:360-375.e5 (2018). PubMed: 30057275
  • Byrnes LE  et al. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun 9:3922 (2018). PubMed: 30254276
  • Tomic G  et al. Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. Cell Stem Cell 23:436-443.e7 (2018). PubMed: 30100168
  • Shaib AH  et al. Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons. Front Cell Neurosci 12:304 (2018). PubMed: 30254567
  • Martinez-Valbuena I  et al. Interaction of amyloidogenic proteins in pancreatic ß cells from subjects with synucleinopathies. Acta Neuropathol N/A:N/A (2018). IHC-P ; Human . PubMed: 29536165
  • Norum JH  et al. The tankyrase inhibitor G007-LK inhibits small intestine LGR5+stem cell proliferation without altering tissue morphology. Biol Res 51:3 (2018). IHC-P ; Mouse . PubMed: 29316982
  • Chua CW  et al. Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation. Elife 7:N/A (2018). PubMed: 29334357
  • Eguchi T  et al. Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment. PLoS One 13:e0191109 (2018). PubMed: 29415026
  • Guarize J  et al. MicroRNA expression profile in primary lung cancer cells lines obtained by endobronchial ultrasound transbronchial needle aspiration. J Thorac Dis 10:408-415 (2018). PubMed: 29600073
  • Lyons J  et al. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol 16:e2002417 (2018). PubMed: 29596476
  • Herring CA  et al. Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut. Cell Syst 6:37-51.e9 (2018). PubMed: 29153838
  • Smith NR  et al. Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations. Cell Mol Gastroenterol Hepatol 6:79-96 (2018). PubMed: 29928673
  • Thomsen SK  et al. Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic ß-cells. Nat Genet 50:1122-1131 (2018). PubMed: 30054598
  • Curtin C  et al. A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models. Acta Biomater 70:84-97 (2018). WB . PubMed: 29447961
  • Zhang L  et al. Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells. Cell Signal 29:41-51 (2017). PubMed: 27511963
  • Wieck MM  et al. Prolonged Absence of Mechanoluminal Stimulation in Human Intestine Alters the Transcriptome and Intestinal Stem Cell Niche. Cell Mol Gastroenterol Hepatol 3:367-388.e1 (2017). PubMed: 28462379
  • Liu M  et al. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem Cell Reports 9:1961-1975 (2017). ICC/IF ; Mouse . PubMed: 29129684
  • Szczyrba J  et al. Neuroendocrine Cells of the Prostate Derive from the Neural Crest. J Biol Chem 292:2021-2031 (2017). PubMed: 28003366
  • Robinson SC  et al. Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells. Cell Commun Signal 15:24 (2017). PubMed: 28637464
  • Stephens SB  et al. The Prohormone VGF Regulates ß Cell Function via Insulin Secretory Granule Biogenesis. Cell Rep 20:2480-2489 (2017). WB, ICC/IF . PubMed: 28877479
  • Wang Y  et al. Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells. Cell Mol Gastroenterol Hepatol 4:165-182.e7 (2017). PubMed: 29204504
  • Farrell AS  et al. MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nat Commun 8:1728 (2017). PubMed: 29170413
  • Niño DF  et al. Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock 47:22-32 (2017). PubMed: 27488085
  • Takahashi Y  et al. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine 23:34-45 (2017). PubMed: 28789943
  • Yanai H  et al. Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity. Sci Rep 7:9891 (2017). PubMed: 28860595
  • Gamper I  et al. Determination of the physiological and pathological roles of E2F3 in adult tissues. Sci Rep 7:9932 (2017). PubMed: 28855541
  • Cedeno RJ  et al. The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment. PLoS One 12:e0185196 (2017). PubMed: 28934364
  • Miyoshi H  et al. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J 36:5-24 (2017). PubMed: 27797821
  • Yuan H  et al. HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes. Sci Rep 7:45617 (2017). IHC-P ; Human . PubMed: 28378747
  • Jadhav U  et al. Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell 21:65-77.e5 (2017). PubMed: 28648363
  • Yissachar N  et al. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell 168:1135-1148.e12 (2017). PubMed: 28262351
  • Saloustros E  et al. Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis. Endocr Relat Cancer 24:31-40 (2017). PubMed: 27803029
  • Engel NW  et al. Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium. PLoS One 11:e0166690 (2016). IHC-P ; Mouse . PubMed: 27902722
  • Tattoli I  et al. NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation. Cell Rep 14:2576-86 (2016). PubMed: 26971996
  • Weiss V  et al. Immunohistochemical analysis of the Wnt/ß-catenin signaling pathway in pancreatic neuroendocrine neoplasms. World J Gastrointest Oncol 8:615-22 (2016). PubMed: 27574554
  • Ravindran R  et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:523-7 (2016). IHC-P ; Mouse . PubMed: 26982722
  • Nakagawa A  et al. Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains. Sci Rep 6:20390 (2016). IHC-P ; Mouse . PubMed: 26856877
  • Fielitz K  et al. Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells. Oncotarget 7:74415-74426 (2016). IHC-P ; Mouse . PubMed: 27769070
  • Wei J  et al. Rapid progression of mixed neuroendocrine carcinoma-acinar adenocarcinoma of the prostate: A case report. Oncol Lett 12:1019-1022 (2016). IHC-P ; Human . PubMed: 27446387
  • Sui X  et al. Prostate cancer metastasis to the distal phalanx of the left hallux: The first confirmed case and literature review. Oncol Lett 12:1074-1078 (2016). IHC-P ; Human . PubMed: 27446396
  • Takada Y  et al. Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Development 143:3532-3539 (2016). PubMed: 27510977
  • Cao C  et al. An unusual mediastinal parathyroid carcinoma coproducing PTH and PTHrP: A case report. Oncol Lett 11:4113-4116 (2016). PubMed: 27313750
  • Watanabe N  et al. Requirement of Gaq/Ga11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis. Cell Mol Gastroenterol Hepatol 2:767-782.e6 (2016). PubMed: 28174748
  • Chiacchiera F  et al. PRC2 preserves intestinal progenitors and restricts secretory lineage commitment. EMBO J 35:2301-2314 (2016). IHC-P . PubMed: 27585866
  • Engevik AC  et al. The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach. Cell Mol Gastroenterol Hepatol 2:605-624 (2016). PubMed: 27990460
  • Wieck MM  et al. Human and Murine Tissue-Engineered Colon Exhibit Diverse Neuronal Subtypes and Can Be Populated by Enteric Nervous System Progenitor Cells When Donor Colon Is Aganglionic. Tissue Eng Part A 22:53-64 (2016). PubMed: 26414777
  • Schumacher MA  et al. The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol 593:1809-27 (2015). Flow Cyt, IHC-P . PubMed: 25605613
  • Bertaux-Skeirik N  et al. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog 11:e1004663 (2015). Flow Cyt . PubMed: 25658601
  • Pierre JF  et al. The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 309:G431-42 (2015). PubMed: 26185331
  • Davis H  et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med 21:62-70 (2015). IHC . PubMed: 25419707
  • Simpson PD  et al. Striking Oxygen Sensitivity of the Peptidylglycine a-Amidating Monooxygenase (PAM) in Neuroendocrine Cells. J Biol Chem 290:24891-901 (2015). WB ; Human . PubMed: 26296884
  • McFarlane MR  et al. Scap is required for sterol synthesis and crypt growth in intestinal mucosa. J Lipid Res 56:1560-71 (2015). PubMed: 25896350
  • Stancikova J  et al. NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling. Cell Signal 27:245-56 (2015). IHC ; Mouse . PubMed: 25446263
  • Mogoanta SS  et al. A nonfunctional neuroendocrine tumor of the pancreas - a case report. Rom J Morphol Embryol 56:511-9 (2015). IHC ; Human . PubMed: 26193221
  • Kitajima S  et al. Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells 33:1657-69 (2015). PubMed: 25694388
  • Chang PC  et al. Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells. PLoS One 9:e88556 (2014). IHC-P ; Human . PubMed: 24551118
  • Makarev E & Gorivodsky M Islet1 and its co-factor ldb1 are expressed in quiescent cells of mouse intestinal epithelium. PLoS One 9:e95256 (2014). IHC-P ; Mouse . PubMed: 24755910
  • Kober OI  et al. ?d T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer. Am J Physiol Gastrointest Liver Physiol 306:G582-93 (2014). ICC/IF ; Mouse . PubMed: 24503767
  • Pinheiro PS  et al. The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. J Neurosci 34:10688-700 (2014). PubMed: 25100601
  • Mounir Z  et al. TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation. Oncogene N/A:N/A (2014). PubMed: 25263440
  • Terry NA  et al. Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. Am J Physiol Gastrointest Liver Physiol 307:G979-91 (2014). PubMed: 25214396
  • McFarlane MR  et al. Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. Cell Metab 20:54-60 (2014). PubMed: 24836560
  • Davis H  et al. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut : (2013). PubMed: 23676439
  • König K  et al. Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS One 8:e57996 (2013). IHC-P ; Mouse . PubMed: 23536778
  • Wrzosek L  et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol 11:61 (2013). WB ; Mouse, Human . PubMed: 23692866
  • Pedersen J  et al. Glucose metabolism is altered after loss of L cells and a-cells but not influenced by loss of K cells. Am J Physiol Endocrinol Metab 304:E60-73 (2013). PubMed: 23115082
  • Weisbrod AB  et al. Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors. Horm Cancer 4:165-75 (2013). IHC-P ; Human . PubMed: 23361940
  • Powell AE  et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149:146-58 (2012). PubMed: 22464327
  • Duca FA  et al. Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota. PLoS One 7:e39748 (2012). IHC . PubMed: 22768116
  • IJssennagger N  et al. Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon. Gut 61:1041-9 (2012). PubMed: 21948946
  • Habib AM  et al. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology 153:3054-65 (2012). PubMed: 22685263
  • Hughes KR  et al. Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon. Am J Physiol Gastrointest Liver Physiol 303:G1188-201 (2012). PubMed: 22997199
  • Konsavage WM  et al. The Myc 3' Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol 32:3891-902 (2012). PubMed: 22826434
  • Angus-Hill ML  et al. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A 108:4914-9 (2011). IHC-Fr ; Mouse . PubMed: 21383188
  • Kim TH & Shivdasani RA Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med 208:677-88 (2011). PubMed: 21402740
  • Zhou D  et al. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A : (2011). PubMed: 22042863
  • Martin P  et al. Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition. Am J Pathol 179:422-35 (2011). IHC-P ; Mouse . PubMed: 21703421
  • Arnold K  et al. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9:317-29 (2011). PubMed: 21982232
  • Chandra R  et al. Pseudopod-like basal cell processes in intestinal cholecystokinin cells. Cell Tissue Res 341:289-97 (2010). PubMed: 20582553
  • Wilson CH  et al. The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. Oncogene 29:4567-75 (2010). PubMed: 20531296
  • Duckworth CA & Pritchard DM Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice. Gastroenterology 136:943-52 (2009). IHC-P ; Mouse . PubMed: 19185578
  • Begus-Nahrmann Y  et al. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet 41:1138-43 (2009). IHC-P ; Mouse . PubMed: 19718028
  • Jeon TI  et al. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J Clin Invest 118:3693-700 (2008). IHC-P ; Mouse . PubMed: 18846256
  • Haigis K  et al. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem 281:638-47 (2006). PubMed: 16258171

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