• Product name
    Anti-Chromogranin A antibody [EP1031Y]
    See all Chromogranin A primary antibodies
  • Description
    Rabbit monoclonal [EP1031Y] to Chromogranin A
  • Host species
  • Tested applications
    Suitable for: WB, IP, IHC-Pmore details
    Unsuitable for: Flow Cyt or ICC
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide within Human Chromogranin A (C terminal). The exact sequence is proprietary.
    (Peptide available as ab138920)

  • Positive control
    • PC12 cytoplasmic cell lysate Human pancreatic tissue
  • General notes


    A trial size is available to purchase for this antibody.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab52983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1e+006. Detects a band of approximately 80-90 kDa (predicted molecular weight: 51 kDa).Can be blocked with Chromogranin A peptide (ab138920).
IP 1/30.
IHC-P 1/250 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt or ICC.
  • Target

    • Function
      Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
    • Sequence similarities
      Belongs to the chromogranin/secretogranin protein family.
    • Post-translational
      Sulfated on tyrosine residues and/or contains sulfated glycans.
      O-glycosylated with core 1 or possibly core 8 glycans.
    • Cellular localization
      Secreted. Neuroendocrine and endocrine secretory granules.
    • Information by UniProt
    • Database links
    • Form
      According to the Swiss-Prot database, this protein has many different forms which correspond to various molecular weights; thus the possible variation from the predicted molecular weight of 51kDa.
    • Alternative names
      • beta Granin antibody
      • betagranin (N-terminal fragment of chromogranin A) antibody
      • catestatin antibody
      • CgA antibody
      • CHG A antibody
      • Chga antibody
      • chromofungin antibody
      • Chromogranin A antibody
      • Chromogranin A parathyroid secretory protein 1 antibody
      • Chromogranin A precursor antibody
      • ChromograninA antibody
      • CMGA_HUMAN antibody
      • ER-37 antibody
      • Pancreastatin antibody
      • Parastatin antibody
      • Parathyroid secretory protein 1 antibody
      • Pituitary secretory protein I antibody
      • Secretory protein I antibody
      • SP I antibody
      • SP-I antibody
      • SP1 antibody
      • SPI antibody
      • vasostatin 2 antibody
      • Vasostatin antibody
      • Vasostatin I antibody
      • Vasostatin II antibody
      • vasostatin-2 antibody
      see all


    • ab52983, at a 1/250 dilution, staining Human Chromogranin A in Pancreas using Immunohistochemistry, Paraffin Emebedded tissue.
    • Anti-Chromogranin A antibody [EP1031Y] (ab52983) at 1/1000000 dilution + PC12 cell lysate at 10 µg

      goat anti-rabbit HRP labelled at 1/2000 dilution

      Predicted band size: 51 kDa
      Observed band size: 80-90 kDa
      why is the actual band size different from the predicted?

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD


    This product has been referenced in:
    • Thomsen SK  et al. Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic ß-cells. Nat Genet 50:1122-1131 (2018). Read more (PubMed: 30054598) »
    • Simpson PD  et al. Striking Oxygen Sensitivity of the Peptidylglycine a-Amidating Monooxygenase (PAM) in Neuroendocrine Cells. J Biol Chem 290:24891-901 (2015). WB ; Human . Read more (PubMed: 26296884) »
    See all 2 Publications for this product

    Customer reviews and Q&As


    Thank you for contacting us.

    As requested, the blocking peptide for the Chromogranin A antibody ab52983 has been added to our catalogue. The catalogue reference number is ab138920 and the link to the datasheet is https://www.abcam.com/ab138920.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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