Overview

  • Product name

    Chromomycin A3, fluorescent DNA stain
  • Description

    Anthraquinone antibiotic, fluorescent DNA stain
  • Biological description

    Anthraquinone antibiotic, fluorescent DNA stain. Binds transcription factors Sp1 and SP3 to DNA to inhibit RNA synthesis. Shows anti-bacterial, anti-fungal and antitumor activities. Active in vivo.
  • Purity

    > 97%
  • CAS Number

    7059-24-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Chromomycin A3
  • Molecular weight

    1183.25
  • Molecular formula

    C57H82O26
  • PubChem identifier

    656673
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Das JK & Khuda-Bukhsh AR GC-rich heterochromatin in silver stained nucleolar organizer regions (NORs) fluoresces with Chromomycin A3 (CMA3) staining in three species of teleostean fishes (Pisces). Indian J Exp Biol 45:413-8 (2007). Read more (PubMed: 17569281) »
  • Mir MA  et al. Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3. Bioorg Med Chem 11:2791-801 (2003). Read more (PubMed: 12788353) »
  • Conti G & Portincasa P Chromomycin A3 inhibits influenza a virus multiplication in chick embryo fibroblast cells. New Microbiol 25:385-98 (2002). Read more (PubMed: 12437217) »

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