Chrysamine G, beta-amyloid inhibitor (ab219402)
- Datasheet
- References
Overview
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Product name
Chrysamine G, beta-amyloid inhibitor -
Description
β-amyloid inhibitor -
Alternative names
- Brasilamina Yellow G
- C.I. Direct Yellow 1
- Chrysamine
see all -
Biological description
Lipophilic, carboxylic acid analog of Congo red (ab145645), shown to bind to the β-amyloid protein in vitro. Binding to the β-amyloid protein inhibits its neurodegenerative activity. Chrysamine G inhibits β-amyloid due to its antioxidant acitvity. Crosses the blood-brain barrier and serves as a useful probe for detecting β-amyloid aggregates.
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CAS Number
6472-91-9 -
Chemical structure
Properties
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Chemical name
4,4'-Bis(3-carboxy-4-hydroxyphenylazo)biphenyl
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Molecular weight
482.44 -
Molecular formula
C26H16N4O6 -
PubChem identifier
6913223 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O)NN=C4C=CC(=O)C(=C4)C(=O)O -
Source
Synthetic
Associated products
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Related Products
References
This product has been referenced in:
- Yang F et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280:5892-901 (2005). Read more (PubMed: 15590663) »
- Mathis CA et al. Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Des 10:1469-92 (2004). Read more (PubMed: 15134570) »
- Ishii K et al. Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice. Neurosci Lett 333:5-8 (2002). Read more (PubMed: 12401547) »
- Klunk WE et al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci 63:1807-14 (1998). Read more (PubMed: 9820124) »
