Chrysamine G, beta-amyloid inhibitor (ab219402)

Overview

  • Product name

    Chrysamine G, beta-amyloid inhibitor
  • Description

    β-amyloid inhibitor
  • Alternative names

    • Brasilamina Yellow G
    • C.I. Direct Yellow 1
    • Chrysamine
    • Chrysamine A
    • Chrysamine Yellow M
    • Diazine Yellow 2G
    • Kayaku Chrysamine G
    see all
  • Biological description

    Lipophilic, carboxylic acid analog of Congo red (ab145645), shown to bind to the β-amyloid protein in vitro. Binding to the β-amyloid protein inhibits its neurodegenerative activity. Chrysamine G inhibits β-amyloid due to its antioxidant acitvity. Crosses the blood-brain barrier and serves as a useful probe for detecting β-amyloid aggregates.

  • CAS Number

    6472-91-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4,4'-Bis(3-carboxy-4-hydroxyphenylazo)biphenyl

  • Molecular weight

    482.44
  • Molecular formula

    C26H16N4O6
  • PubChem identifier

    6913223
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O)NN=C4C=CC(=O)C(=C4)C(=O)O
  • Source

    Synthetic

Associated products

References

This product has been referenced in:

  • Yang F  et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280:5892-901 (2005). Read more (PubMed: 15590663) »
  • Mathis CA  et al. Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Des 10:1469-92 (2004). Read more (PubMed: 15134570) »
  • Ishii K  et al. Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice. Neurosci Lett 333:5-8 (2002). Read more (PubMed: 12401547) »
  • Klunk WE  et al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci 63:1807-14 (1998). Read more (PubMed: 9820124) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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