Overview

  • Product name

    CHS-828, NF-kappabeta inhibitor
  • Description

    NF-κβ inhibitor. Potent antineoplastic agent
  • Biological description

    NF-κβ inhibitor. Potent antineoplastic agent. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    200484-11-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[6-(4-Chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine
  • Molecular weight

    371.86
  • Molecular formula

    C19H22ClN5O
  • PubChem identifier

    148198
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Johanson V  et al. Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice. Neuroendocrinology 82:171-6 (2005). Read more (PubMed: 16508338) »
  • Hjarnaa PJ  et al. CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res 59:5751-7 (1999). Read more (PubMed: 10582695) »
  • Hassan SB  et al. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. Anticancer Res 26:4431-6 (0). Read more (PubMed: 17201165) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142208.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up