Overview

  • Product name
    Anti-Chymotrypsin antibody [4E1]
    See all Chymotrypsin primary antibodies
  • Description
    Mouse monoclonal [4E1] to Chymotrypsin
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-P, ICC/IF, IHC-Fr, ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Full length native pancreatic protein (purified) (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab35694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
IHC-Fr 1/100 - 1/800.
ELISA 1/20000.
WB 1/400 - 1/4000. Predicted molecular weight: 29 kDa.

Target

  • Function
    Has chymotrypsin-type protease activity and hypocalcemic activity.
  • Tissue specificity
    Pancreas.
  • Involvement in disease
    Variations in CTRC influence susceptibility to chronic pancreatitis [MIM:167800]. Chronic pancreatitis is a persistent inflammatory disorder characterized by permanent destruction of the pancreatic parenchyma.
  • Sequence similarities
    Belongs to the peptidase S1 family. Elastase subfamily.
    Contains 1 peptidase S1 domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • Caldecrin antibody
    • Chymotrypsin C antibody
    • Chymotrypsin-C antibody
    • ChymotrypsinC antibody
    • CLCR antibody
    • Ctrc antibody
    • CTRC_HUMAN antibody
    • ELA 4 antibody
    • ELA4 antibody
    • Elastase 4 antibody
    • Elastase IV antibody
    • Elastase4 antibody
    • ElastaseIV antibody
    • OTTHUMP00000044526 antibody
    • Serum calcium decreasing factor antibody
    see all

References

This product has been referenced in:
  • Song Y  et al. Label-Free Quantitative Proteomics Unravels Carboxypeptidases as the Novel Biomarker in Pancreatic Ductal Adenocarcinoma. Transl Oncol 11:691-699 (2018). WB ; Human . Read more (PubMed: 29631213) »
  • Hong X  et al. Challenges in detecting pre-malignant pancreatic lesions during acute pancreatitis using a serum microRNA assay: a study based on KrasG12D transgenic mice. Oncotarget 7:22700-10 (2016). Read more (PubMed: 27009811) »
See all 5 Publications for this product

Customer reviews and Q&As

Answer

Thank you for contacting Abcam regarding our anti-chymotrypsin antibodies. I have compared the human and porcine chemotrypsin sequences and overall, they share 84% identity.  Unfortunately, we have not mapped the epitopes recognized by these antibodies, so it is not possible to know if the regions of homology correlate to the sequences recognized by these antibodies. I am happy to offer a testing discount whereby you order one or both of these antibodies, test them with your porcine samples and submit your results in the form of an Abreview.  Once the review(s) has been submitted, the discount codes I will provide will become active and can be used towards a free primary antibody on your next purchase from us.  Please reply to this email and I will issue the code(s). I hope this information is helpful.  Please do not hesitate to contact us if you have any additional questions.

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up